Modulation of the Cardiac Transient Outward Potassium Current by CaMKII is Dependent on Lipid Rafts Integrity

Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases.

AIMS The human cardiac transient outward K(+) current I(to) (encoded by Kv4.3 or KCND3) plays an important role in phase 1 rapid repolarization of cardiac action potentials in the heart. However, modulation of I(to) by intracellular signal transduction is not fully understood. The present study was therefore designed to determine whether/how human atrial I(to) and hKv4.3 channels stably express...

Transient outward potassium current in ICC.

Interstitial cells of Cajal (ICC) are the pacemakers of the gut, initiating slow-wave activity. Several ion channels have been identified that contribute to the depolarization phase of the slow wave. Our aim was to contribute to knowledge about the identity and role of ICC potassium channels in pacemaking. Here we describe a transient outward potassium current in cell-attached patches of ICC. T...

Title Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases

Transient outward current, Ito1, is altered in cardiac memory.

BACKGROUND Cardiac memory refers to an altered T-wave morphology induced by ventricular pacing or arrhythmias that persist for variable intervals after resumption of sinus rhythm. METHODS AND RESULTS We induced long-term cardiac memory (LTM) in conscious dogs by pacing the ventricles at 120 bpm for 3 weeks. ECGs were recorded daily for 1 hour, during which time pacing was discontinued. At ter...

Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.

AIMS The transient outward potassium current (I(to)) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study the effects and mechanisms of I(to) on EAD genesis in cardiac cells using combined experimental and computational approaches. METHODS AND RESULTS We first car...